====== Richard E. Zigmond, Ph.D. ====== #template(faculty_profile.php|... * FName: Richard E. * LName: Zigmond * Degree: Ph.D. * Picture: zigmond-1.jpg * Width: 200 * Position: Professor * Department: Department of Neurosciences * Organization: Case Western Reserve University * Address_1: School of Medicine, Room E701 * Address_2: 10900 Euclid Avenue * Address_3: Cleveland OH, 44106-4975 * Phone: (216) 368-4614 * Fax: (216) 368-4650 * Email: rez@case.edu * Web: [[zigmond_lab|Zigmond Lab Page]] * PubMed_Search: Zigmond RE )# ===== RESEARCH INTERESTS ===== My laboratory studies neurochemical plasticity in adult neurons. We are interested in the ways in which the chemistry of the adult nervous system can change and the functional consequences of such changes. We focus particularly on alterations that occur in response to (1) neural damage and (2) changes in the electrical activity. Currently, we are focusing on the molecules and cells involved in altering neuronal gene expression in response to axonal injury. Previous research has established that, when a neuron's axon is severed, it decreases its synthesis of a number of proteins involved in neurotransmission and increases its synthesis of other proteins involved in regeneration. We find that, following axotomy, sympathetic neurons in the rat superior cervical ganglion express vasoactive intestinal peptide (VIP) and galanin, two neuropeptides not normally expressed by these neurons. These changes are detected both at the peptide and mRNA levels. Similar changes occur if adult ganglia are placed in either explant or dissociated cultures, allowing us to use these in vitro systems to study the molecular mechanisms involved. Our studies have shown that these changes in neuropeptide expression are triggered at least in part by the induction of the cytokine leukemia inhibitory factor (LIF) by non-neuronal cells and the reduction of the target-derived trophic factor nerve growth factor (NGF) both of which occur after transection of sympathetic axons. A number of lines of evidence suggest that VIP and galanin promote neuronal survival and/or axonal regeneration. Strikingly, changes in both of these peptides occur in two other types of peripheral neurons after axonal injury, namely, sensory and motor neurons. We are exploring the consequences of these changes both on peripheral neurons and on non-neuronal cells to determine the mechanisms by which they can affect regeneration. ===== SELECTED PUBLICATIONS ===== #template?key=Zigmond(dokudata.php|... * Author: Zigmond RE, Vaccariello SA. * Year: 2007 * Title: Activating transcription factor 3 immunoreactivity identifies small populations of axotomized neurons in rat cervical sympathetic ganglia after transection of the preganglionic cervical sympathetic trunk. * Journal: Brain Res. * Volume: 1159 * Pages: 119-23 * Selected: true ---- * Author: Shoemaker SE, Sachs HH, Vacariello SA, Zigmond RE. * Year: 2006 * Title: Reduction in nerve growth factor availability leads to a conditioning lesion-like effect in sympathetic neurons. * Journal: J Neurobiol. * Volume: 66 * Pages: 1322-1337 * Selected: true * Student: true ---- * ID: 16022869 * Author: Shoemaker SE, Sachs HH, Vaccariello SA, Zigmond RE. * Volume: 194 * Issue: 2 * Year: 2005 * Date: 2005 Aug * Journal: Exp Neurol * Pages: 432-443 * Title: A conditioning lesion enhances sympathetic neurite outgrowth. * Selected: true * Student: true ---- * ID: 15464282 * Author: Schreiber RC, Boeshore KL, Laube G, Veh RW, Zigmond RE. * Volume: 128 * Issue: 4 * Year: 2004 * Date: 2004 * Journal: Neuroscience * Pages: 741-749 * Title: Polyamines increase in sympathetic neurons and non-neuronal cells after axotomy and enhance neurite outgrowth in nerve growth factor-primed PC12 cells. * Selected: true ---- * ID: 15085539 * Author: Boeshore KL, Schreiber RC, Vaccariello SA, Sachs HH, Salazar R, Lee J, Ratan RR, Leahy P, Zigmond RE. * Volume: 59 * Issue: 2 * Year: 2004 * Date: 2004 May * Journal: J Neurobiol * Pages: 216-235 * Title: Novel changes in gene expression following axotomy of a sympathetic ganglion: a microarray analysis. * Selected: true * Postdoc: true ---- * ID: 15080892 * Author: Nielsen KM, Chaverra M, Hapner SJ, Nelson BR, Todd V, Zigmond RE, Lefcort F. * Volume: 25 * Issue: 4 * Year: 2004 * Date: 2004 Apr * Journal: Mol Cell Neurosci * Pages: 629-641 * Title: PACAP promotes sensory neuron differentiation: blockade by neurotrophic factors. * Selected: true ---- * ID: 12360584 * Author: Schreiber RC, Vaccariello SA, Boeshore K, Shadiack AM, Zigmond RE. * Volume: 53 * Issue: 1 * Year: 2002 * Date: 2002 Oct * Journal: J Neurobiol * Pages: 68-79 * Title: A comparison of the changes in the non-neuronal cell populations of the superior cervical ganglia following decentralization and axotomy. * Selected: true ---- * ID: 11799243 * Author: Takasu MA, Dalva MB, Zigmond RE, Greenberg ME. * Volume: 295 * Issue: 5554 * Year: 2002 * Date: 2002 Jan 18 * Journal: Science * Pages: 491-495 * Title: Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors. * Status: 2001/12/20 [aheadofprint] * Selected: true ---- * ID: 11506868 * Author: Zigmond RE. * Volume: 24 * Issue: 9 * Year: 2001 * Date: 2001 Sep * Journal: Trends Neurosci * Pages: 494-6; discussion 496 * Title: Can galanin also be considered as growth-associated protein 3.2? * Selected: true ---- * ID: 11234772 * Author: Schreiber RC, Krivacic K, Kirby B, Vaccariello SA, Wei T, Ransohoff RM, Zigmond RE. * Volume: 12 * Issue: 3 * Year: 2001 * Date: 2001 Mar 5 * Journal: Neuroreport * Pages: 601-606 * Title: Monocyte chemoattractant protein (MCP)-1 is rapidly expressed by sympathetic ganglion neurons following axonal injury. * Selected: true ---- * ID: 11193812 * Author: Zigmond RE. * Volume: 921 * Issue: * Year: 2000 * Date: 2000 * Journal: Ann N Y Acad Sci * Pages: 103-108 * Title: Neuropeptide action in sympathetic ganglia. Evidence for distinct functions in intact and axotomized ganglia. * Selected: true ---- * ID: 11169504 * Author: Zhou Y, Deneris E, Zigmond RE. * Volume: 46 * Issue: 3 * Year: 2001 * Date: 2001 Feb 15 * Journal: J Neurobiol * Pages: 178-192 * Title: Nicotinic acetylcholine receptor subunit proteins alpha7 and beta4 decrease in the superior cervical ganglion after axotomy. * Selected: true * Student: true ---- * ID: 11160417 * Author: Shadiack AM, Sun Y, Zigmond RE. * Volume: 21 * Issue: 2 * Year: 2001 * Date: 2001 Jan 15 * Journal: J Neurosci * Pages: 363-371 * Title: Nerve growth factor antiserum induces axotomy-like changes in neuropeptide expression in intact sympathetic and sensory neurons. * Selected: true * Postdoc: true ---- * ID: 10864965 * Author: Bibevski S, Zhou Y, McIntosh JM, Zigmond RE, Dunlap ME. * Volume: 20 * Issue: 13 * Year: 2000 * Date: 2000 Jul 1 * Journal: J Neurosci * Pages: 5076-5082 * Title: Functional nicotinic acetylcholine receptors that mediate ganglionic transmission in cardiac parasympathetic neurons. * Selected: true * Student: true ---- * ID: 10623897 * Author: Ip NY, Zigmond RE. * Volume: 42 * Issue: 1 * Year: 2000 * Date: 2000 Jan * Journal: J Neurobiol * Pages: 14-21 * Title: Synergistic effects of muscarinic agonists and secretin or vasoactive intestinal peptide on the regulation of tyrosine hydroxylase activity in sympathetic neurons. * Student: true * Postdoc: true ---- * ID: 10413445 * Author: Rittenhouse AR, Zigmond RE. * Volume: 40 * Issue: 2 * Year: 1999 * Date: 1999 Aug * Journal: J Neurobiol * Pages: 137-148 * Title: Role of N- and L-type calcium channels in depolarization-induced activation of tyrosine hydroxylase and release of norepinephrine by sympathetic cell bodies and nerve terminals. * Selected: true * Postdoc: true ---- * ID: 10366607 * Author: Boeshore KL, Luckey CN, Zigmond RE, Large TH. * Volume: 19 * Issue: 12 * Year: 1999 * Date: 1999 Jun 15 * Journal: J Neurosci * Pages: 4739-4747 * Title: TrkB isoforms with distinct neurotrophin specificities are expressed in predominantly nonoverlapping populations of avian dorsal root ganglion neurons. * Student: true ---- * ID: 10363928 * Author: Mohney RP, Zigmond RE. * Volume: 10 * Issue: 6 * Year: 1999 * Date: 1999 Apr 26 * Journal: Neuroreport * Pages: 1221-1224 * Title: Galanin expression is decreased by cAMP-elevating agents in cultured sympathetic ganglia. * Student: true ---- * ID: 10217263 * Author: Nagamoto-Combs K, Vaccariello SA, Zigmond RE. * Volume: 72 * Issue: 5 * Year: 1999 * Date: 1999 May * Journal: J Neurochem * Pages: 1871-1881 * Title: The levels of leukemia inhibitory factor mRNA in a Schwann cell line are regulated by multiple second messenger pathways. * Selected: true * Postdoc: true ---- * ID: 10189060 * Author: Shadiack AM, Zigmond RE. * Volume: 32 * Issue: 3 * Year: 1998 * Date: 1998 Jun * Journal: Neuropeptides * Pages: 257-264 * Title: Galanin induced in sympathetic neurons after axotomy is anterogradely transported toward regenerating nerve endings. * Postdoc: true ---- * ID: 9651211 * Author: Mohney RP, Zigmond RE. * Volume: 18 * Issue: 14 * Year: 1998 * Date: 1998 Jul 15 * Journal: J Neurosci * Pages: 5285-5293 * Title: Vasoactive intestinal peptide enhances its own expression in sympathetic neurons after injury. * Selected: true * Student: true ---- * ID: 9636218 * Author: Shadiack AM, Vaccariello SA, Sun Y, Zigmond RE. * Volume: 95 * Issue: 13 * Year: 1998 * Date: 1998 Jun 23 * Journal: Proc Natl Acad Sci U S A * Pages: 7727-7730 * Title: Nerve growth factor inhibits sympathetic neurons' response to an injury cytokine. * Selected: true * Postdoc: true ---- * ID: 9468387 * Author: Zhou Y, Deneris E, Zigmond RE. * Volume: 34 * Issue: 2 * Year: 1998 * Date: 1998 Feb 5 * Journal: J Neurobiol * Pages: 164-178 * Title: Differential regulation of levels of nicotinic receptor subunit transcripts in adult sympathetic neurons after axotomy. * Selected: true * Student: true ---- * ID: 9327836 * Author: Zigmond RE. * Volume: 42 * Issue: * Year: 1998 * Date: 1998 * Journal: Adv Pharmacol * Pages: 21-25 * Title: Regulation of tyrosine hydroxylase by neuropeptides. ---- * ID: 9160971 * Author: Zigmond RE, Sun Y. * Volume: 814 * Issue: * Year: 1997 * Date: 1997 Apr 24 * Journal: Ann N Y Acad Sci * Pages: 181-197 * Title: Regulation of neuropeptide expression in sympathetic neurons. Paracrine and retrograde influences. ---- * ID: 8921314 * Author: Sun Y, Zigmond RE. * Volume: 8 * Issue: 10 * Year: 1996 * Date: 1996 Oct * Journal: Eur J Neurosci * Pages: 2213-2220 * Title: Leukaemia inhibitory factor induced in the sciatic nerve after axotomy is involved in the induction of galanin in sensory neurons. * Selected: true * Student: true ---- * ID: 8858962 * Author: Sun Y, Zigmond RE. * Volume: 67 * Issue: 4 * Year: 1996 * Date: 1996 Oct * Journal: J Neurochem * Pages: 1751-1760 * Title: Involvement of leukemia inhibitory factor in the increases in galanin and vasoactive intestinal peptide mRNA and the decreases in neuropeptide Y and tyrosine hydroxylase mRNA in sympathetic neurons after axotomy. * Student: true ---- * ID: 8844517 * Author: Hyatt-Sachs H, Bachoo M, Schreiber R, Vaccariello SA, Zigmond RE. * Volume: 30 * Issue: 4 * Year: 1996 * Date: 1996 Aug * Journal: J Neurobiol * Pages: 543-555 * Title: Chemical sympathectomy and postganglionic nerve transection produce similar increases in galanin and VIP mRNA but differ in their effects on peptide content. ---- * ID: 8731483 * Author: Sun Y, Landis SC, Zigmond RE. * Volume: 7 * Issue: 2 * Year: 1996 * Date: 1996 Feb * Journal: Mol Cell Neurosci * Pages: 152-163 * Title: Signals triggering the induction of leukemia inhibitory factor in sympathetic superior cervical ganglia and their nerve trunks after axonal injury. * Student: true ---- * ID: 9169921 * Author: Zigmond RE, Hyatt-Sachs H, Mohney RP, Schreiber RC, Shadiack AM, Sun Y, Vaccariello SA. * Volume: 4 * Issue: 1 * Year: 1996 * Date: 1996 * Journal: Perspect Dev Neurobiol * Pages: 75-90 * Title: Changes in neuropeptide phenotype after axotomy of adult peripheral neurons and the role of leukemia inhibitory factor. * Selected: true ---- * ID: 7658197 * Author: Schreiber RC, Shadiack AM, Bennett TA, Sedwick CE, Zigmond RE. * Volume: 27 * Issue: 2 * Year: 1995 * Date: 1995 Jun * Journal: J Neurobiol * Pages: 141-153 * Title: Changes in the macrophage population of the rat superior cervical ganglion after postganglionic nerve injury. ---- * ID: 7542372 * Author: Shadiack AM, Vaccariello SA, Zigmond RE. * Volume: 65 * Issue: 4 * Year: 1995 * Date: 1995 Apr * Journal: Neuroscience * Pages: 1119-1127 * Title: Galanin expression in sympathetic ganglia after partial axotomy is highly localized to those neurons that are axotomized. * Postdoc: true ---- * ID: 7524215 * Author: Zigmond RE. * Volume: 17 * Issue: 7 * Year: 1994 * Date: 1994 Jul * Journal: Trends Neurosci * Pages: 297-299 * Title: Axotomy changes peptide expression. ---- * ID: 7519758 * Author: Schreiber RC, Hyatt-Sachs H, Bennett TA, Zigmond RE. * Volume: 60 * Issue: 1 * Year: 1994 * Date: 1994 May * Journal: Neuroscience * Pages: 17-27 * Title: Galanin expression increases in adult rat sympathetic neurons after axotomy. ---- * ID: 8077967 * Author: Sun Y, Rao MS, Zigmond RE, Landis SC. * Volume: 25 * Issue: 4 * Year: 1994 * Date: 1994 Apr * Journal: J Neurobiol * Pages: 415-430 * Title: Regulation of vasoactive intestinal peptide expression in sympathetic neurons in culture and after axotomy: the role of cholinergic differentiation factor/leukemia inhibitory factor. * Student: true ---- * ID: 7517435 * Author: Mohney RP, Siegel RE, Zigmond RE. * Volume: 25 * Issue: 2 * Year: 1994 * Date: 1994 Feb * Journal: J Neurobiol * Pages: 108-118 * Title: Galanin and vasoactive intestinal peptide messenger RNAs increase following axotomy of adult sympathetic neurons. * Student: true ---- * ID: 8245973 * Author: Schulz DW, Kuchel GA, Zigmond RE. * Volume: 61 * Issue: 6 * Year: 1993 * Date: 1993 Dec * Journal: J Neurochem * Pages: 2225-2232 * Title: Decline in response to nicotine in aged rat striatum: correlation with a decrease in a subpopulation of nicotinic receptors. * Postdoc: true ---- * ID: 7506046 * Author: Rao MS, Sun Y, Escary JL, Perreau J, Tresser S, Patterson PH, Zigmond RE, Brulet P, Landis SC. * Volume: 11 * Issue: 6 * Year: 1993 * Date: 1993 Dec * Journal: Neuron * Pages: 1175-1185 * Title: Leukemia inhibitory factor mediates an injury response but not a target-directed developmental transmitter switch in sympathetic neurons. * Student: true ---- * ID: 7686961 * Author: Rao MS, Sun Y, Vaidyanathan U, Landis SC, Zigmond RE. * Volume: 24 * Issue: 5 * Year: 1993 * Date: 1993 May * Journal: J Neurobiol * Pages: 571-580 * Title: Regulation of substance P is similar to that of vasoactive intestinal peptide after axotomy or explantation of the rat superior cervical ganglion. * Student: true ---- * ID: 8097667 * Author: McKeon TW, Zigmond RE. * Volume: 607 * Issue: 1-2 * Year: 1993 * Date: 1993 Apr 2 * Journal: Brain Res * Pages: 345-348 * Title: Vasoactive intestinal peptide and secretin produce long-term increases in tyrosine hydroxylase activity in the rat superior cervical ganglion. * Postdoc: true ---- * ID: 8463841 * Author: Hyatt-Sachs H, Schreiber RC, Bennett TA, Zigmond RE. * Volume: 13 * Issue: 4 * Year: 1993 * Date: 1993 Apr * Journal: J Neurosci * Pages: 1642-1653 * Title: Phenotypic plasticity in adult sympathetic ganglia in vivo: effects of deafferentation and axotomy on the expression of vasoactive intestinal peptide. ---- * ID: 1486495 * Author: Piszczkiewicz S, Zigmond RE. * Volume: 598 * Issue: 1-2 * Year: 1992 * Date: 1992 Dec 11 * Journal: Brain Res * Pages: 327-331 * Title: Is the vasoactive intestinal peptide-like immunoreactivity in the rat pineal gland present in fibers originating in the superior cervical ganglion? * Student: true ---- * ID: 1383475 * Author: Sun Y, Rao MS, Landis SC, Zigmond RE. * Volume: 12 * Issue: 10 * Year: 1992 * Date: 1992 Oct * Journal: J Neurosci * Pages: 3717-3728 * Title: Depolarization increases vasoactive intestinal peptide- and substance P-like immunoreactivities in cultured neonatal and adult sympathetic neurons. * Student: true ---- * ID: 1741405 * Author: Zigmond RE, Hyatt-Sachs H, Baldwin C, Qu XM, Sun Y, McKeon TW, Schreiber RC, Vaidyanathan U. * Volume: 89 * Issue: 4 * Year: 1992 * Date: 1992 Feb 15 * Journal: Proc Natl Acad Sci U S A * Pages: 1507-1511 * Title: Phenotypic plasticity in adult sympathetic neurons: changes in neuropeptide expression in organ culture. ---- * ID: 1815824 * Author: Sasek CA, Baldwin C, Zigmond RE. * Volume: 567 * Issue: 1 * Year: 1991 * Date: 1991 Dec 13 * Journal: Brain Res * Pages: 159-164 * Title: Distribution of vasoactive intestinal peptide- and peptide histidine isoleucine amide-like immunoreactive neurons and fibers in the thoracic spinal cord of the rat. ---- * ID: 1680163 * Author: Waymire JC, Craviso GL, Lichteig K, Johnston JP, Baldwin C, Zigmond RE. * Volume: 57 * Issue: 4 * Year: 1991 * Date: 1991 Oct * Journal: J Neurochem * Pages: 1313-1324 * Title: Vasoactive intestinal peptide stimulates catecholamine biosynthesis in isolated adrenal chromaffin cells: evidence for a cyclic AMP-dependent phosphorylation and activation of tyrosine hydroxylase. ---- * ID: 2054611 * Author: Kuchel GA, Zigmond RE. * Volume: 540 * Issue: 1-2 * Year: 1991 * Date: 1991 Feb 1 * Journal: Brain Res * Pages: 195-203 * Title: Functional recovery and collateral neuronal sprouting examined in young and aged rats following a partial neural lesion. ---- * ID: 1703218 * Author: Schwarzschild MA, Zigmond RE. * Volume: 56 * Issue: 2 * Year: 1991 * Date: 1991 Feb * Journal: J Neurochem * Pages: 400-406 * Title: Effects of peptides of the secretin-glucagon family and cyclic nucleotides on tyrosine hydroxylase activity in sympathetic nerve endings. ---- * ID: 1671089 * Author: Rittenhouse AR, Zigmond RE. * Volume: 56 * Issue: 2 * Year: 1991 * Date: 1991 Feb * Journal: J Neurochem * Pages: 615-622 * Title: Omega-conotoxin inhibits the acute activation of tyrosine hydroxylase and the stimulation of norepinephrine release by potassium depolarization of sympathetic nerve endings. ---- * ID: 1986068 * Author: Schulz DW, Loring RH, Aizenman E, Zigmond RE. * Volume: 11 * Issue: 1 * Year: 1991 * Date: 1991 Jan * Journal: J Neurosci * Pages: 287-297 * Title: Autoradiographic localization of putative nicotinic receptors in the rat brain using 125I-neuronal bungarotoxin. ---- * ID: 1711174 * Author: Baldwin C, Sasek CA, Zigmond RE. * Volume: 40 * Issue: 1 * Year: 1991 * Date: 1991 * Journal: Neuroscience * Pages: 175-184 * Title: Evidence that some preganglionic sympathetic neurons in the rat contain vasoactive intestinal peptide- or peptide histidine isoleucine amide-like immunoreactivities. ---- * ID: 1976030 * Author: Rittenhouse AR, Zigmond RE. * Volume: 524 * Issue: 1 * Year: 1990 * Date: 1990 Jul 30 * Journal: Brain Res * Pages: 156-159 * Title: Nerve stimulation in vivo acutely increases tyrosine hydroxylase activity in the superior cervical ganglion and its end organs. ---- * ID: 12106093 * Author: Loring RH, Zigmond RE. * Volume: 2 * Issue: 10 * Year: 1990 * Date: 1990 * Journal: Eur J Neurosci * Pages: 863-872 * Title: Pharmacological and Biochemical Properties of Nicotinic Receptors from Chick Retina. ---- * ID: 2133350 * Author: Kuchel GA, Sherman RL, Zigmond RE. * Volume: 37 * Issue: 2 * Year: 1990 * Date: 1990 * Journal: Neuroscience * Pages: 413-420 * Title: Recovery of function following unilateral denervation, but not unilateral decentralization, of the pineal gland as indicated by measurements of pineal melatonin content and urinary melatonin metabolites. ---- * ID: 2573012 * Author: Biguet NF, Rittenhouse AR, Mallet J, Zigmond RE. * Volume: 104 * Issue: 1-2 * Year: 1989 * Date: 1989 Sep 25 * Journal: Neurosci Lett * Pages: 189-194 * Title: Preganglionic nerve stimulation increases mRNA levels for tyrosine hydroxylase in the rat superior cervical ganglion. ---- * ID: 2746336 * Author: Loring RH, Aizenman E, Lipton SA, Zigmond RE. * Volume: 9 * Issue: 7 * Year: 1989 * Date: 1989 Jul * Journal: J Neurosci * Pages: 2423-2431 * Title: Characterization of nicotinic receptors in chick retina using a snake venom neurotoxin that blocks neuronal nicotinic receptor function. ---- * ID: 2566962 * Author: Schulz DW, Zigmond RE. * Volume: 98 * Issue: 3 * Year: 1989 * Date: 1989 Apr 10 * Journal: Neurosci Lett * Pages: 310-316 * Title: Neuronal bungarotoxin blocks the nicotinic stimulation of endogenous dopamine release from rat striatum. ---- * ID: 2708564 * Author: Sasek CA, Zigmond RE. * Volume: 280 * Issue: 4 * Year: 1989 * Date: 1989 Feb 22 * Journal: J Comp Neurol * Pages: 522-532 * Title: Localization of vasoactive intestinal peptide- and peptide histidine isoleucine amide-like immunoreactivities in the rat superior cervical ganglion and its nerve trunks. ---- * ID: 2685893 * Author: Loring RH, Schulz DW, Zigmond RE. * Volume: 79 * Issue: * Year: 1989 * Date: 1989 * Journal: Prog Brain Res * Pages: 109-116 * Title: Characterization of neuronal nicotinic receptors using neuronal bungarotoxin. ---- * ID: 2570376 * Author: Schwarzschild MA, Vale W, Corigliano-Murphy AC, Pisano JJ, Ip NY, Zigmond RE. * Volume: 31 * Issue: 1 * Year: 1989 * Date: 1989 * Journal: Neuroscience * Pages: 159-167 * Title: Activation of ganglionic tyrosine hydroxylase by peptides of the secretin-glucagon family: structure-function studies. ---- * ID: 2564757 * Author: Zigmond RE, Schwarzschild MA, Rittenhouse AR. * Volume: 12 * Issue: * Year: 1989 * Date: 1989 * Journal: Annu Rev Neurosci * Pages: 415-461 * Title: Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation. ---- * ID: 2563276 * Author: Schwarzschild MA, Zigmond RE. * Volume: 9 * Issue: 1 * Year: 1989 * Date: 1989 Jan * Journal: J Neurosci * Pages: 160-166 * Title: Secretin and vasoactive intestinal peptide activate tyrosine hydroxylase in sympathetic nerve endings. ---- * ID: 2899305 * Author: Rittenhouse AR, Schwarzschild MA, Zigmond RE. * Volume: 25 * Issue: 1 * Year: 1988 * Date: 1988 Apr * Journal: Neuroscience * Pages: 207-215 * Title: Both synaptic and antidromic stimulation of neurons in the rat superior cervical ganglion acutely increase tyrosine hydroxylase activity. ---- * ID: 3380297 * Author: Loring RH, Sah DW, Landis SC, Zigmond RE. * Volume: 24 * Issue: 3 * Year: 1988 * Date: 1988 Mar * Journal: Neuroscience * Pages: 1071-1080 * Title: The ultrastructural distribution of putative nicotinic receptors on cultured neurons from the rat superior cervical ganglion. ---- * ID: 2465603 * Author: Loring RH, Zigmond RE. * Volume: 11 * Issue: 2 * Year: 1988 * Date: 1988 Feb * Journal: Trends Neurosci * Pages: 73-78 * Title: Characterization of neuronal nicotinic receptors by snake venom neurotoxins. ---- * ID: 2908454 * Author: Zigmond RE. * Volume: 83 * Issue: 3 * Year: 1988 * Date: 1988-89 * Journal: J Physiol (Paris) * Pages: 267-271 * Title: A comparison of the long-term and short-term regulations of tyrosine hydroxylase activity. ---- * ID: 3681404 * Author: Lingappa JR, Zigmond RE. * Volume: 7 * Issue: 11 * Year: 1987 * Date: 1987 Nov * Journal: J Neurosci * Pages: 3525-3528 * Title: Pineal transplants in oculo: limitations on the ability of collateral sprouts of foreign neurons to establish normal function. ---- * ID: 3612234 * Author: Loring RH, Zigmond RE. * Volume: 7 * Issue: 7 * Year: 1987 * Date: 1987 Jul * Journal: J Neurosci * Pages: 2153-2162 * Title: Ultrastructural distribution of 125I-toxin F binding sites on chick ciliary neurons: synaptic localization of a toxin that blocks ganglionic nicotinic receptors. ---- * ID: 3627441 * Author: Lingappa JR, Zigmond RE. * Volume: 21 * Issue: 3 * Year: 1987 * Date: 1987 Jun * Journal: Neuroscience * Pages: 893-902 * Title: A histochemical study of the adrenergic innervation of the rat pineal gland: evidence for overlap of the innervation from the two superior cervical ganglia and for sprouting following unilateral denervation. ---- * ID: 3037434 * Author: Sah DW, Loring RH, Zigmond RE. * Volume: 20 * Issue: 3 * Year: 1987 * Date: 1987 Mar * Journal: Neuroscience * Pages: 867-874 * Title: Long-term blockade by toxin F of nicotinic synaptic potentials in cultured sympathetic neurons. ---- * ID: 3021284 * Author: Loring RH, Andrews D, Lane W, Zigmond RE. * Volume: 385 * Issue: 1 * Year: 1986 * Date: 1986 Oct 15 * Journal: Brain Res * Pages: 30-37 * Title: Amino acid sequence of toxin F, a snake venom toxin that blocks neuronal nicotinic receptors. ---- * ID: 2862951 * Author: Ip NY, Zigmond RE. * Volume: 338 * Issue: 1 * Year: 1985 * Date: 1985 Jul 8 * Journal: Brain Res * Pages: 61-70 * Title: Long-term regulation of tyrosine hydroxylase activity in the superior cervical ganglion in organ culture: effects of nerve stimulation and dexamethasone. ---- * ID: 2862228 * Author: Ip NY, Baldwin C, Zigmond RE. * Volume: 5 * Issue: 7 * Year: 1985 * Date: 1985 Jul * Journal: J Neurosci * Pages: 1947-1954 * Title: Regulation of the concentration of adenosine 3',5'-cyclic monophosphate and the activity of tyrosine hydroxylase in the rat superior cervical ganglion by three neuropeptides of the secretin family. ---- * ID: 3990957 * Author: Loring RH, Dahm LM, Zigmond RE. * Volume: 14 * Issue: 2 * Year: 1985 * Date: 1985 Feb * Journal: Neuroscience * Pages: 645-660 * Title: Localization of alpha-bungarotoxin binding sites in the ciliary ganglion of the embryonic chick: an autoradiographic study at the light and electron microscopic level. ---- * ID: 3965639 * Author: Zigmond RE, Baldwin C, Bowers CW. * Volume: 5 * Issue: 1 * Year: 1985 * Date: 1985 Jan * Journal: J Neurosci * Pages: 142-150 * Title: Rapid recovery of pineal function after partial denervation: a possible role for heteroneuronal uptake of transmitter in modulating synaptic efficacy. ---- * ID: 6148705 * Author: Ip NY, Zigmond RE. * Volume: 311 * Issue: 5985 * Year: 1984 * Date: 1984 Oct 4-10 * Journal: Nature * Pages: 472-474 * Title: Pattern of presynaptic nerve activity can determine the type of neurotransmitter regulating a postsynaptic event. ---- * ID: 6493487 * Author: Bowers CW, Dahm LM, Zigmond RE. * Volume: 13 * Issue: 1 * Year: 1984 * Date: 1984 Sep * Journal: Neuroscience * Pages: 87-96 * Title: The number and distribution of sympathetic neurons that innervate the rat pineal gland. ---- * ID: 6208508 * Author: Ip NY, Zigmond RE. * Volume: 13 * Issue: 1 * Year: 1984 * Date: 1984 Sep * Journal: Neuroscience * Pages: 217-220 * Title: Substance P inhibits the acute stimulation of ganglionic tyrosine hydroxylase activity by a nicotinic agonist. ---- * ID: 6470764 * Author: Bowers CW, Baldwin C, Zigmond RE. * Volume: 4 * Issue: 8 * Year: 1984 * Date: 1984 Aug * Journal: J Neurosci * Pages: 2010-2015 * Title: Sympathetic reinnervation of the pineal gland after postganglionic nerve lesion does not restore normal pineal function. ---- * ID: 6330611 * Author: Loring RH, Chiappinelli VA, Zigmond RE, Cohen JB. * Volume: 11 * Issue: 4 * Year: 1984 * Date: 1984 Apr * Journal: Neuroscience * Pages: 989-999 * Title: Characterization of a snake venom neurotoxin which blocks nicotinic transmission in the avian ciliary ganglion. ---- * ID: 6147816 * Author: Ip NY, Baldwin C, Zigmond RE. * Volume: 5 * Issue: 2 * Year: 1984 * Date: 1984 Mar-Apr * Journal: Peptides * Pages: 309-312 * Title: Acute stimulation of ganglionic tyrosine hydroxylase activity by secretin, VIP and PHI. ---- * ID: 6132384 * Author: Ip NY, Perlman RL, Zigmond RE. * Volume: 80 * Issue: 7 * Year: 1983 * Date: 1983 Apr * Journal: Proc Natl Acad Sci U S A * Pages: 2081-2085 * Title: Acute transsynaptic regulation of tyrosine 3-monooxygenase activity in the rat superior cervical ganglion: evidence for both cholinergic and noncholinergic mechanisms. ---- * ID: 6130526 * Author: Ip NY, Ho CK, Zigmond RE. * Volume: 79 * Issue: 23 * Year: 1982 * Date: 1982 Dec * Journal: Proc Natl Acad Sci U S A * Pages: 7566-7569 * Title: Secretin and vasoactive intestinal peptide acutely increase tyrosine 3-monooxygenase in the rat superior cervical ganglion. ---- * ID: 6127400 * Author: Ip NY, Perlman RL, Zigmond RE. * Volume: 223 * Issue: 2 * Year: 1982 * Date: 1982 Nov * Journal: J Pharmacol Exp Ther * Pages: 280-283 * Title: Both nicotinic and muscarinic agonists acutely increase tyrosine 3-monooxygenase activity in the superior cervical ganglion. ---- * ID: 7175744 * Author: Bowers CW, Zigmond RE. * Volume: 330 * Issue: * Year: 1982 * Date: 1982 Sep * Journal: J Physiol * Pages: 279-296 * Title: The influence of the frequency and pattern of sympathetic nerve activity on serotonin N-acetyltransferase in the rat pineal gland. ---- * ID: 6267612 * Author: Zigmond RE, Baldwin C, Bowers CW. * Volume: 78 * Issue: 6 * Year: 1981 * Date: 1981 Jun * Journal: Proc Natl Acad Sci U S A * Pages: 3959-3963 * Title: Rapid recovery of function after partial denervation of the rat pineal gland suggests a novel mechanism for neural plasticity. ---- * ID: 6261879 * Author: Chiappinelli VA, Cohen JB, Zigmond RE. * Volume: 211 * Issue: 1 * Year: 1981 * Date: 1981 Apr 27 * Journal: Brain Res * Pages: 107-126 * Title: The effects of alpha- and beta-neurotoxins from the venoms of various snakes on transmission in autonomic ganglia. ---- * ID: 7204667 * Author: Rando TA, Bowers CW, Zigmond RE. * Volume: 196 * Issue: 1 * Year: 1981 * Date: 1981 Feb 10 * Journal: J Comp Neurol * Pages: 73-83 * Title: Localization of neurons in the rat spinal cord which project to the superior cervical ganglion. ---- * ID: 7301125 * Author: Bowers CW, Zigmond RE. * Volume: 6 * Issue: 9 * Year: 1981 * Date: 1981 * Journal: Neuroscience * Pages: 1783-1791 * Title: Sympathetic neurons in lower cervical ganglia send axons through the superior cervical ganglion. ---- * ID: 6164015 * Author: Gamse R, Wax A, Zigmond RE, Leeman SE. * Volume: 6 * Issue: 3 * Year: 1981 * Date: 1981 * Journal: Neuroscience * Pages: 437-441 * Title: Immunoreactive substance P in sympathetic ganglia: distribution and sensitivity towards capsaicin. ---- * ID: 6111290 * Author: Zigmond RE, Bowers CW. * Volume: 43 * Issue: * Year: 1981 * Date: 1981 * Journal: Annu Rev Physiol * Pages: 673-687 * Title: Influence of nerve activity of the macromolecular content of neurons and their effector organs. ---- * ID: 6133253 * Author: Zigmond RE, Chalazonitis A, Joh T. * Volume: 20 * Issue: 1 * Year: 1980 * Date: 1980 Oct 20 * Journal: Neurosci Lett * Pages: 61-65 * Title: Preganglionic nerve stimulation increases the amount of tyrosine hydroxylase in the rat superior cervical ganglion. ---- * ID: 6106563 * Author: Zigmond RE. * Volume: 39 * Issue: 12 * Year: 1980 * Date: 1980 Oct * Journal: Fed Proc * Pages: 3003-3008 * Title: The long-term regulation of ganglionic tyrosine hydroxylase by preganglionic nerve activity. ---- * ID: 6102147 * Author: Chalazonitis A, Rice PJ, Zigmond RE. * Volume: 213 * Issue: 1 * Year: 1980 * Date: 1980 Apr * Journal: J Pharmacol Exp Ther * Pages: 139-143 * Title: Increased ganglionic tyrosine hydroxylase and dopamine-beta-hydroxylase activities following preganglionic nerve stimulation: role of nicotine receptors. ---- * ID: 7357437 * Author: Bowers CW, Zigmond RE. * Volume: 185 * Issue: 2 * Year: 1980 * Date: 1980 Mar 10 * Journal: Brain Res * Pages: 435-440 * Title: Electrical stimulation of the cerivcal sympathetic trunks mimics the effects of darkness on the activity of serotonin:N-acetyltransferase in the rat pineal. ---- * ID: 6103955 * Author: Chalazonitis A, Zigmond RE. * Volume: 300 * Issue: * Year: 1980 * Date: 1980 Mar * Journal: J Physiol * Pages: 525-538 * Title: Effects of synaptic and antidromic stimulation on tyrosine hydroxylase activity in the rat superior cervical ganglion. ---- * ID: 7357391 * Author: Zigmond RE, Detrick RA, Pfaff DW. * Volume: 182 * Issue: 2 * Year: 1980 * Date: 1980 Jan 27 * Journal: Brain Res * Pages: 369-381 * Title: An autoradiographic study of the localization of androgen concentrating cells in the chaffinch. ---- * ID: 429622 * Author: Bowers CW, Zigmond RE. * Volume: 185 * Issue: 2 * Year: 1979 * Date: 1979 May 15 * Journal: J Comp Neurol * Pages: 381-391 * Title: Localization of neurons in the rat superior cervical ganglion that project into different postganglionic trunks. ---- * ID: 34466 * Author: Zigmond RE, Chalazonitis A. * Volume: 164 * Issue: * Year: 1979 * Date: 1979 Mar 23 * Journal: Brain Res * Pages: 137-152 * Title: Long-term effects of preganglionic nerve stimulation on tyrosine hydroxylase activity in the rat superior cervical ganglion. ---- * ID: 32230 * Author: Zigmond RE. * Volume: 32 * Issue: 1 * Year: 1979 * Date: 1979 Jan * Journal: J Neurochem * Pages: 23-29 * Title: Tyrosine hydroxylase activity in noradrenergic neurons of the locus coeruleus after reserpine administration: sequential increase in cell bodies and nerve terminals. ---- * ID: 208083 * Author: Chiappinelli VA, Zigmond RE. * Volume: 75 * Issue: 6 * Year: 1978 * Date: 1978 Jun * Journal: Proc Natl Acad Sci U S A * Pages: 2999-3003 * Title: alpha-Bungarotoxin blocks nicotinic transmission in the avian ciliary ganglion. ---- * ID: 19742 * Author: Zigmond RE, Ben-Ari Y. * Volume: 74 * Issue: 7 * Year: 1977 * Date: 1977 Jul * Journal: Proc Natl Acad Sci U S A * Pages: 3078-3080 * Title: Electrical stimulation of preganglionic nerve increases tyrosine hydroxylase activity in sympathetic ganglia. )# #template?query=Selected&key=Zigmond(publications.php|...)# ===== STUDENTS FIRST AUTHOR PUBLICATIONS ===== #template?query=Student&key=Zigmond(publications.php|...)# ===== POSTDOCS FIRST AUTHOR PUBLICATIONS ===== #template?query=Postdoc&key=Zigmond(publications.php|...)# #template?key=Zigmond(dokudata.php|...)# (space) ===== STUDENTS JOB PLACEMENT ===== #template(current_positions.php|... * Title: Ph.D. Student ---- * Name: **Chauncey W. Bowers, Ph.D.** * Position: **Assistant Research Scientist** \\ Division of Neuroscience \\ Beckman Research Institute \\ The City of Hope \\ 1450 E. Duarte Rd \\ Duarte CA 91010 ---- * Name: **Nancy Ip, Ph.D.** * Position: **Chair Professor and Director of the Biotechnology Research Institute** \\ Department of Biochemistry \\ Hong Kong University of Science and Technology \\ Clear Water Bay \\ Kowloon, Hong Kong ---- * Name: **Jaisri R. Lingappa, M.D., Ph.D.** * Position: **Associate Professor of Pathobiology** \\ Adjunct Assistant Professor of Medicine \\ University of Washington \\ Room F161B \\ Box 357238 \\ 1959 NE Pacific St. \\ Seattle, WA 98195-7238 ---- * Name: **Robert P. Mohney, Ph.D.** * Position: **Project Leader** \\ Metabolon Inc \\ 800 Capitola Drive, Suite 1 \\ Durham, NC 27713 ---- * Name: **Michael Schwarzschild, M.D., Ph.D.** * Position: **Associate Professor** \\ Molecular Neurobiology \\ MGH East, CNY-6, Rm 6024 \\ Bldg 149 13th Street \\ Charlestown MA 02129 ---- * Name: **Yi Sun, Ph.D.** * Position: **Assistant Professor** \\ Department of Psychiatry and Biobehavioral Sciences \\ UCLA \\ Los Angeles, CA )# (space) ===== POSTDOCS AND RESEARCH ASSOCIATES JOB PLACEMENT ===== #template(current_positions.php|... * Title: Postdoc / R.A. ---- * Name: **Dr. Alcmene Chalazonitis** * Position: **Research Scientist** \\ Department of Anatomy and Cell Biology \\ Columbia University CPS \\ 630 W. 168th Street \\ New York NY 10032 ---- * Name: **Vincent A. Chiappinelli, Ph.D.** * Position: **Chair and Professor of Pharmacology** \\ Dept. of Pharmacology \\ George Washington University School of Medicine \\ 2300 Eye Street NW \\ Washington DC 20037 ---- * Name: **Ralph H. Loring, Ph.D.** * Position: **Associate Professor** \\ Department of Pharmaceutical Sciences \\ Northeastern University \\ 211 Mugar Hall \\ Boston MA 02215 ---- * Name: **Ann R. Rittenhouse, Ph.D.** * Position: **Associate Professor** \\ Dept. of Physiology \\ University of Massachusetts Medical Center \\ 55 Lake Ave. North \\ Worcester MA 01655 ---- * Name: **Catherine A. Sasek, PhD** * Position: **Health Scientist Administrator** \\ National Institute on Drug Abuse \\ 5600 Fishers Lane, Room 10A-55 \\ Rockville MD 20857 ---- * Name: **David W. Schulz** * Position: **Manager** \\ Pfizer Central Research \\ Department of Neuroscience \\ Groton CT 06340 ---- * Name: **Annette M. Shadiack, Ph.D.** * Position: **Executive Director** \\ Preclinical Development \\ Palatin Technologies, Inc. \\ 4C Cedarbrook Dr. \\ Cranbury, NJ 08512 ---- * Name: **Kristen Boeshore, Ph.D.** * Position: **Assistant Professor** \\ Biology Department \\ Lebanon Valley College \\ 101 N. College Ave. \\ Annville, PA 17003 )# (space) ~~NOTOC~~