Neurosciences

School of Medicine

User Tools

Site Tools


faculty:pehek:index

Elizabeth A. Pehek, Ph.D.

Elizabeth A. Pehek, Ph.D.
Associate Professor
Department of Psychiatry and Neurosciences
Case Western Reserve University


Cleveland VA Medical Center 151(W)
10701 East Blvd Cleveland, OH 44106

Phone : (216) 791-3800 x4237
Fax : (216) 229-8509
Email : eap6@case.edu
 
 

RESEARCH INTERESTS

General research interests are the neuropharmacology and neurochemistry of brain pathways implicated in the regulation of mood, cognition, and reward. Specific interests include the regulation of brain dopamine and glutamate release by dopamine and serotonin receptor subtypes in the prefrontal cortex, limbic system, and basal ganglia of the rat. For these studies, neurotransmitter release is measured in vivo by brain microdialysis coupled with HPLC and electrochemical detection. Regulation in the midbrain, where dopamine cell bodies reside, is contrasted with regulation in dopamine terminal fields. In other work, the neuroanatomical basis for serotonin-dopamine interactions is investigated in both the midbrain and prefrontal cortex by immunocytochemical methods. The overall goal of the laboratory is to elucidate the neuronal circuitry regulating the activity of dopaminergic neurons involved in stress responses, drug abuse, and mental disorders such as schizophrenia and depression.

SELECTED PUBLICATIONS

  1. Pehek EA, Nocjar C, Roth BL, Byrd TA, Mabrouk OS. (2006)
    Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Neuropsychopharmacology. 2006 Feb; 31(2):265-277.
  2. Alex KD, Yavanian GJ, McFarlane HG, Pluto CP, Pehek EA. (2005)
    Modulation of dopamine release by striatal 5-HT2C receptors. Synapse. 2005 Mar 15; 55(4):242-251.
  3. Saklayen SS, Mabrouk OS, Pehek EA. (2004)
    Negative feedback regulation of nigrostriatal dopamine release: mediation by striatal D1 receptors. J Pharmacol Exp Ther. 2004 Oct; 311(1):342-348. 2004/06/02 [aheadofprint].
  4. Hendricks TJ, Fyodorov DV, Wegman LJ, Lelutiu NB, Pehek EA, Yamamoto B, Silver J, Weeber EJ, Sweatt JD, Deneris ES. (2003)
    Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron. 2003 Jan 23; 37(2):233-247.
  5. Pehek EA, McFarlane HG, Maguschak K, Price B, Pluto CP. (2001)
    M100,907, a selective 5-HT(2A) antagonist, attenuates dopamine release in the rat medial prefrontal cortex. Brain Res. 2001 Jan 5; 888(1):51-59.
  6. Pehek EA. (1999)
    Comparison of effects of haloperidol administration on amphetamine-stimulated dopamine release in the rat medial prefrontal cortex and dorsal striatum. J Pharmacol Exp Ther. 1999 Apr; 289(1):14-23.
  7. Pehek EA, Bi Y. (1997)
    Ritanserin administration potentiates amphetamine-stimulated dopamine release in the rat prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry. 1997 May; 21(4):671-682.
  8. Pehek EA. (1996)
    Local infusion of the serotonin antagonists ritanserin or ICS 205,930 increases in vivo dopamine release in the rat medial prefrontal cortex. Synapse. 1996 Sep; 24(1):12-18.
  9. Pehek EA, Yamamoto BK. (1994)
    Differential effects of locally administered clozapine and haloperidol on dopamine efflux in the rat prefrontal cortex and caudate-putamen. J Neurochem. 1994 Dec; 63(6):2118-2124.
  10. Yamamoto BK, Pehek EA, Meltzer HY. (1994)
    Brain region effects of clozapine on amino acid and monoamine transmission. J Clin Psychiatry. 1994 Sep; 55 Suppl B:8-14.

GRADUATE STUDENT FIRST AUTHOR PUBLICATIONS

  1. Alex KD, Yavanian GJ, McFarlane HG, Pluto CP, Pehek EA. (2005)
    Modulation of dopamine release by striatal 5-HT2C receptors. Synapse. 2005 Mar 15; 55(4):242-251.

JOB PLACEMENT OF STUDENTS AND POSTDOCS

Students and PostdocsCurrent Position
Christine Nocjar, Ph.D.Instructor, Department of Psychiatry, CWRU

 

faculty/pehek/index.txt ยท Last modified: 2014/11/26 03:33 (external edit)