Department of Psychiatry and Neurosciences
Case Western Reserve University
Cleveland VA Medical Center 151(W)
General research interests are the neuropharmacology and neurochemistry of brain pathways implicated in the regulation of mood, cognition, and reward. Specific interests include the regulation of brain dopamine and glutamate release by dopamine and serotonin receptor subtypes in the prefrontal cortex, limbic system, and basal ganglia of the rat. For these studies, neurotransmitter release is measured in vivo by brain microdialysis coupled with HPLC and electrochemical detection. Regulation in the midbrain, where dopamine cell bodies reside, is contrasted with regulation in dopamine terminal fields. In other work, the neuroanatomical basis for serotonin-dopamine interactions is investigated in both the midbrain and prefrontal cortex by immunocytochemical methods. The overall goal of the laboratory is to elucidate the neuronal circuitry regulating the activity of dopaminergic neurons involved in stress responses, drug abuse, and mental disorders such as schizophrenia and depression.
|Students and Postdocs||Current Position|
|Christine Nocjar, Ph.D.||Instructor, Department of Psychiatry, CWRU|