====== David M. Katz, Ph.D. ====== #template(faculty_profile.php|... * FName: David M. * LName: Katz * Degree: Ph.D. * Picture:katz_website_photo_reduced.jpg * Width: 300 * Position: Professor * Department: Department of Neurosciences * Organization: Case Western Reserve University * Address_1: School of Medicine, Room E712 * Address_2: 10900 Euclid Ave * Address_3: Cleveland OH, 44106-4975 * Phone: (216) 368-6116 * Fax: (216) 368-4650 * Email: dmk4@case.edu * PubMed_Search: Katz DM )# ===== RESEARCH INTERESTS ===== Our laboratory seeks to define regulatory interactions in the developing nervous system and to understand how perturbations of development result in disease. In particular, we study the role of neuronal growth factors in the functional maturation of neural systems using genetically engineered mice and tissue culture model systems. A major focus of the laboratory is to elucidate the molecular pathogenesis of Rett Syndrome (RTT), a devastating developmental disorder characterized by cognitive, motor and autonomic dysfunction, and to develop potential treatments. In particular, we are studying how loss of MeCP2, the gene mutated in RTT, disrupts expression and secretion of Brain Derived Neurotrophic Factor (BDNF), a protein that is critical for development, function and plasticity of many neurons in the brain and peripheral nervous system. We have found that the normal interplay between neuronal activity, and expression and secretion of BDNF, is dysregulated in MeCP2 null mice. In particular, loss of MeCP2 results in a progressive decline in the ability of neurons to synthesize and secrete normal levels of BDNF after birth. Some of the earliest changes occur in brain structures that are critical for the control of breathing and other homeostatic functions that are adversely affected in Rett patients. In fact, MeCP2 null mice exhibit severe respiratory defects, as in RTT patients. Current efforts are focused on defining underlying mechanisms and on developing BDNF-based therapies for this disease. ===== SELECTED PUBLICATIONS ===== #template?key=Katz(dokudata.php|... ---- * ID: * Author: Taneja, P., Ogier, M., Brooks-Harris, G., Katz, D.M. and S. B. Nelson * Volume: 29 * Issue: * Year: 2009 * Date: * Journal: J. Neurosci. * Pages: 12187-12195 * Title: Pathophysiology of locus coeruleus neurons in a mouse model of Rett Syndrome * Status: * Selected: true ---- * ID: * Author: Ladas, T., Chan, S-A., Ogier, M., Smith, C. and D. M. Katz * Volume: 30 * Issue: 2 * Year: 2009 * Date: * Journal: Eur. J. Neurosci. * Pages: 602-10 * Title: Enhanced dense core granule function and adrenal hypersecretion in a mouse model of Rett Syndrome * Status: * Selected: true ---- * ID: * Author: Katz, D.M., Dutschmann, M., Ramirez, N. and G. Hilaire * Volume: 168 * Issue: * Year: 2009 * Date: * Journal: Resp. Physiol. and Neurobiol. * Pages: 101-8 * Title: Breathing disorders in Rett Syndrome: Progressive neurochemical dysfunction in the respiratory network after birth * Status: * Selected: true ---- * ID: * Author: Bouvier, J., Autran, S., Dehorter, N., Katz, D.M., Champagnat, J., Fortin, G. and Thoby-Brisson, M. * Volume: 28 * Issue: * Year: 2008 * Date: * Journal: J Neurosci * Pages: 510-520 * Title: The embryonic pre-Bötzinger complex is a target of Brain-Derived Neurotrophic Factor * Status: * Selected: true ---- * ID: * Author: Ogier, M., Wang H., Hong, E., Wang, Q., Greenberg, M.E. and D. M. Katz. * Volume: * Issue: * Year: 2007 * Date: * Journal: J Neurosci * Pages: * Title: Brain Derived Neurotrophic Factor and respiratory function improve after ampakine treatment in a mouse model of Rett Syndrome. * Status: **27**:10912-7 * Selected: true ---- * ID: * Author: Wang, H., Chan, S., Ogier, M., Hellard, D., Wang, Q., Smith, C. and D.M. Katz. * Volume: * Issue: * Year: 2006 * Date: * Journal: J Neurosci * Pages: * Title: Dysregulation of BDNF expression and neurosecretion in MeCP2 null mice. * Status: **26**:10911-10915 * Selected: true ---- * ID: * Author: Wang, H., Yuan, G., Ward, N., Boswell, M. and D.M. Katz. * Volume: 96 * Issue: 6 * Year: 2006 * Date: 2006 * Journal: Eur J Neurosci * Pages: 1665-70 * Title: Secretion of brain derived neurotrophic factor from brain microvascular endothelial cells. * Status: * Selected: true ---- * ID: 16390493 * Author: Wang H, Yuan G, Prabhakar NR, Boswell M, Katz DM. * Volume: 96 * Issue: 3 * Year: 2006 * Date: 2006 Feb * Journal: J Neurochem * Pages: 694-705 * Title: Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling. * Status: * Selected: true ---- * ID: 16203214 * Author: Katz DM. * Volume: 149 * Issue: 1-3 * Year: 2005 * Date: 2005 Nov 15 * Journal: Respir Physiol Neurobiol * Pages: 99-109 * Title: Regulation of respiratory neuron development by neurotrophic and transcriptional signaling mechanisms. * Selected: true ---- * ID: 15869495 * Author: Guo H, Hellard DT, Huang L, Katz DM. * Volume: 21 * Issue: 7 * Year: 2005 * Date: 2005 Apr * Journal: Eur J Neurosci * Pages: 2019-2023 * Title: Development of pontine noradrenergic A5 neurons requires brain-derived neurotrophic factor. * Selected: true ---- * ID: 15561428 * Author: Huang L, Guo H, Hellard DT, Katz DM. * Volume: 130 * Issue: 1 * Year: 2005 * Date: 2005 * Journal: Neuroscience * Pages: 95-105 * Title: Glial cell line-derived neurotrophic factor (GDNF) is required for differentiation of pontine noradrenergic neurons and patterning of central respiratory output. * Selected: true ---- * ID: 15464571 * Author: Hellard D, Brosenitsch T, Fritzsch B, Katz DM. * Volume: 275 * Issue: 1 * Year: 2004 * Date: 2004 Nov 1 * Journal: Dev Biol * Pages: 34-43 * Title: Cranial sensory neuron development in the absence of brain-derived neurotrophic factor in BDNF/Bax double null mice. * Selected: true ---- * ID: 12930808 * Author: Thoby-Brisson M, Cauli B, Champagnat J, Fortin G, Katz DM. * Volume: 23 * Issue: 20 * Year: 2003 * Date: 2003 Aug 20 * Journal: J Neurosci * Pages: 7685-7689 * Title: Expression of functional tyrosine kinase B receptors by rhythmically active respiratory neurons in the pre-Botzinger complex of neonatal mice. * Selected: true ---- * ID: 12809616 * Author: Katz DM. * Volume: 135 * Issue: 2-3 * Year: 2003 * Date: 2003 May 30 * Journal: Respir Physiol Neurobiol * Pages: 155-165 * Title: Neuronal growth factors and development of respiratory control. ---- * ID: 12451139 * Author: Balkowiec A, Katz DM. * Volume: 22 * Issue: 23 * Year: 2002 * Date: 2002 Dec 1 * Journal: J Neurosci * Pages: 10399-10407 * Title: Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons. * Selected: true ---- * ID: 12139921 * Author: Brosenitsch TA, Katz DM. * Volume: 20 * Issue: 3 * Year: 2002 * Date: 2002 Jul * Journal: Mol Cell Neurosci * Pages: 447-457 * Title: Expression of Phox2 transcription factors and induction of the dopaminergic phenotype in primary sensory neurons. * Selected: true ---- * ID: 11306610 * Author: Brosenitsch TA, Katz DM. * Volume: 21 * Issue: 8 * Year: 2001 * Date: 2001 Apr 15 * Journal: J Neurosci * Pages: 2571-2579 * Title: Physiological patterns of electrical stimulation can induce neuronal gene expression by activating N-type calcium channels. * Selected: true ---- * ID: 11160437 * Author: Erickson JT, Brosenitsch TA, Katz DM. * Volume: 21 * Issue: 2 * Year: 2001 * Date: 2001 Jan 15 * Journal: J Neurosci * Pages: 581-589 * Title: Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor are required simultaneously for survival of dopaminergic primary sensory neurons //in vivo//. * Selected: true ---- * ID: 11007900 * Author: Balkowiec A, Katz DM. * Volume: 20 * Issue: 19 * Year: 2000 * Date: 2000 Oct 1 * Journal: J Neurosci * Pages: 7417-7423 * Title: Activity-dependent release of endogenous brain-derived neurotrophic factor from primary sensory neurons detected by ELISA in situ. * Selected: true ---- * ID: 10684891 * Author: Balkowiec A, Kunze DL, Katz DM. * Volume: 20 * Issue: 5 * Year: 2000 * Date: 2000 Mar 1 * Journal: J Neurosci * Pages: 1904-1911 * Title: Brain-derived neurotrophic factor acutely inhibits AMPA-mediated currents in developing sensory relay neurons. * Selected: true ---- * ID: 10066266 * Author: Brady R, Zaidi SI, Mayer C, Katz DM. * Volume: 19 * Issue: 6 * Year: 1999 * Date: 1999 Mar 15 * Journal: J Neurosci * Pages: 2131-2142 * Title: BDNF is a target-derived survival factor for arterial baroreceptor and chemoafferent primary sensory neurons. * Selected: true ---- * ID: 9706001 * Author: Balkowiec A, Katz DM. * Volume: 510 ( Pt 2) * Issue: * Year: 1998 * Date: 1998 Jul 15 * Journal: J Physiol * Pages: 527-533 * Title: Brain-derived neurotrophic factor is required for normal development of the central respiratory rhythm in mice. * Selected: true ---- * ID: 9437025 * Author: Brosenitsch TA, Salgado-Commissariat D, Kunze DL, Katz DM. * Volume: 18 * Issue: 3 * Year: 1998 * Date: 1998 Feb 1 * Journal: J Neurosci * Pages: 1047-1055 * Title: A role for L-type calcium channels in developmental regulation of transmitter phenotype in primary sensory neurons. ---- * ID: 9391764 * Author: Katz DM, Balkowiec A. * Volume: 3 * Issue: 6 * Year: 1997 * Date: 1997 Nov * Journal: Curr Opin Pulm Med * Pages: 433-439 * Title: New insights into the ontogeny of breathing from genetically engineered mice. * Selected: true ---- * ID: 8757249 * Author: Erickson JT, Conover JC, Borday V, Champagnat J, Barbacid M, Yancopoulos G, Katz DM. * Volume: 16 * Issue: 17 * Year: 1996 * Date: 1996 Sep 1 * Journal: J Neurosci * Pages: 5361-5371 * Title: Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing. * Selected: true ---- * ID: 7746324 * Author: Conover JC, Erickson JT, Katz DM, Bianchi LM, Poueymirou WT, McClain J, Pan L, Helgren M, Ip NY, Boland P, et al.. * Volume: 375 * Issue: 6528 * Year: 1995 * Date: 1995 May 18 * Journal: Nature * Pages: 235-238 * Title: Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4. * Selected: true ---- )# #template?query=Selected&key=Katz(publications.php|...)# #template?key=Katz(dokudata.php|...)# ~~NOTOC~~