====== Dominique Durand, Ph.D. ====== #template(faculty_profile.php|... * FName: Dominique * LName: Durand * Degree: Ph.D. * Picture: durand-1.jpg * Width: 230 * Position: Professor, Department of Biomedical Engineering * Department: Neural Engineering Center and Biomedical Engineering Department * Organization: Case Western Reserve University * Address_1: Room 112 Wickenden Building * Address_2: Department of Biomedical Engineering \\ Neural Engineering Center * Address_3: Cleveland OH, 44106-4975 * Phone: (216) 368-3974 * Fax: (216) 368-4872 * Email: dominique.durand@case.edu * PubMed_Search: Durand DM + Case Western )# ===== RESEARCH INTERESTS ===== N**eural Engineering** is a new discipline at the interface between engineering and neuroscience. Neural Engineering research in my laboratory combines computational neuroscience, engineering and electrophysiology to solve problems in the central and peripheral nervous systems. In the CNS, the mechanisms of synchronization of neuronal activity during epilepsy are investigated using //in-vitro// brain slice preparations, //in-vivo// multiple electrode recording and computer models. The interaction between applied currents and neuronal tissue are studied to determine the feasibility of controlling seizures in patients with epilepsy. In the peripheral nervous system, novel nerve electrodes are being developed capable of stimulating and recording neuronal activity selectively. This neural interfacing methodology is applied to the hypoglossal nerve to restore patency in the airways in patients with obstructive sleep apnea and to design neural prostheses for patients with spinal cord injury and stroke. Computer simulations of both neurons and volume conductors are used in conjunction with the experiments for the quantitative analysis of neural systems and to design new electrodes for interfacing with the nervous system. ===== SELECTED PUBLICATIONS ===== #template?key=Durand(dokudata.php|... * ID: 16705266 * Author: Leventhal DK, Cohen M, Durand DM. * Volume: 3 * Issue: 2 * Year: 2006 * Date: 2006 Jun * Journal: J Neural Eng * Pages: 102-113 * Title: Chronic histological effects of the flat interface nerve electrode. * Status: 2006/04/18 [aheadofprint] * Selected: true ---- * ID: 16453204 * Author: Lertmanorat Z, Gustafson KJ, Durand DM. * Volume: 34 * Issue: 1 * Year: 2006 * Date: 2006 Jan * Journal: Ann Biomed Eng * Pages: 152-160 * Title: Electrode array for reversing the recruitment order of peripheral nerve stimulation: experimental studies. * Status: 2006/02/02 [aheadofprint] * Selected: true ---- * ID: 16119242 * Author: Yoo PB, Durand DM. * Volume: 52 * Issue: 8 * Year: 2005 * Date: 2005 Aug * Journal: IEEE Trans Biomed Eng * Pages: 1461-1469 * Title: Selective recording of the canine hypoglossal nerve using a multicontact flat interface nerve electrode. * Selected: true ---- * ID: 16085109 * Author: Park EH, Durand DM. * Volume: 238 * Issue: 3 * Year: 2006 * Date: 2006 Feb 7 * Journal: J Theor Biol * Pages: 666-682 * Title: Role of potassium lateral diffusion in non-synaptic epilepsy: a computational study. * Status: 2005/08/08 [aheadofprint] * Selected: true ---- * ID: 15876640 * Author: Lertmanorat Z, Durand DM. * Volume: 1 * Issue: 4 * Year: 2004 * Date: 2004 Dec * Journal: J Neural Eng * Pages: 202-211 * Title: Extracellular voltage profile for reversing the recruitment order of peripheral nerve stimulation: a simulation study. * Status: 2004/11/17 [aheadofprint] * Selected: true ---- * ID: 15876622 * Author: Lian J, Shuai J, Durand DM. * Volume: 1 * Issue: 1 * Year: 2004 * Date: 2004 Mar * Journal: J Neural Eng * Pages: 46-54 * Title: Control of phase synchronization of neuronal activity in the rat hippocampus. * Status: 2004/03/15 [aheadofprint] * Selected: true ---- * ID: 15831801 * Author: Yoo PB, Durand DM. * Volume: 99 * Issue: 3 * Year: 2005 * Date: 2005 Sep * Journal: J Appl Physiol * Pages: 937-943 * Title: Effects of selective hypoglossal nerve stimulation on canine upper airway mechanics. * Status: 2005/04/14 [aheadofprint] * Selected: true ---- * ID: 15567337 * Author: Feng Z, Durand DM. * Volume: 1030 * Issue: 1 * Year: 2004 * Date: 2004 Dec 24 * Journal: Brain Res * Pages: 57-65 * Title: Suppression of excitatory synaptic transmission can facilitate low-calcium epileptiform activity in the hippocampus in vivo. * Status: 2004/09/27 [accepted] * Selected: true ---- * ID: 15496488 * Author: Feng Z, Durand DM. * Volume: 93 * Issue: 3 * Year: 2005 * Date: 2005 Mar * Journal: J Neurophysiol * Pages: 1158-1164 * Title: Decrease in synaptic transmission can reverse the propagation direction of epileptiform activity in hippocampus in vivo. * Status: 2004/10/20 [aheadofprint] * Selected: true ---- * ID: 15376513 * Author: Leventhal DK, Durand DM. * Volume: 51 * Issue: 9 * Year: 2004 * Date: 2004 Sep * Journal: IEEE Trans Biomed Eng * Pages: 1649-1658 * Title: Chronic measurement of the stimulation selectivity of the flat interface nerve electrode. * Selected: true ---- * ID: 15248540 * Author: Lertmanorat Z, Durand DM. * Volume: 51 * Issue: 7 * Year: 2004 * Date: 2004 Jul * Journal: IEEE Trans Biomed Eng * Pages: 1242-1250 * Title: A novel electrode array for diameter-dependent control of axonal excitability: a simulation study. * Selected: true ---- * ID: 15117024 * Author: Yoo PB, Sahin M, Durand DM. * Volume: 32 * Issue: 4 * Year: 2004 * Date: 2004 Apr * Journal: Ann Biomed Eng * Pages: 511-519 * Title: Selective stimulation of the canine hypoglossal nerve using a multi-contact cuff electrode. * Selected: true ---- * ID: 14690275 * Author: Durand DM. * Volume: 106 * Issue: 4 * Year: 2003 * Date: 2003 * Journal: Radiat Prot Dosimetry * Pages: 325-331 * Title: Electric field effects in hyperexcitable neural tissue: a review. * Selected: true ---- * ID: 14619998 * Author: Hsu KH, Nagarajan SS, Durand DM. * Volume: 50 * Issue: 11 * Year: 2003 * Date: 2003 Nov * Journal: IEEE Trans Biomed Eng * Pages: 1276-1285 * Title: Analysis of efficiency of magnetic stimulation. * Selected: true ---- * ID: 14534265 * Author: Feng Z, Durand DM. * Volume: 90 * Issue: 4 * Year: 2003 * Date: 2003 Oct * Journal: J Neurophysiol * Pages: 2253-2260 * Title: Low-calcium epileptiform activity in the hippocampus in vivo. * Selected: true ---- * ID: 12797613 * Author: Leventhal DK, Durand DM. * Volume: 31 * Issue: 6 * Year: 2003 * Date: 2003 Jun * Journal: Ann Biomed Eng * Pages: 643-652 * Title: Subfascicle stimulation selectivity with the flat interface nerve electrode. * Selected: true ---- * ID: 12797612 * Author: Tyler DJ, Durand DM. * Volume: 31 * Issue: 6 * Year: 2003 * Date: 2003 Jun * Journal: Ann Biomed Eng * Pages: 633-642 * Title: Chronic response of the rat sciatic nerve to the flat interface nerve electrode. * Selected: true ---- * ID: 12611367 * Author: Tyler DJ, Durand DM. * Volume: 10 * Issue: 4 * Year: 2002 * Date: 2002 Dec * Journal: IEEE Trans Neural Syst Rehabil Eng * Pages: 294-303 * Title: Functionally selective peripheral nerve stimulation with a flat interface nerve electrode. * Selected: true ---- * ID: 12609911 * Author: Shuai J, Bikson M, Hahn PJ, Lian J, Durand DM. * Volume: 84 * Issue: 3 * Year: 2003 * Date: 2003 Mar * Journal: Biophys J * Pages: 2099-2111 * Title: Ionic mechanisms underlying spontaneous CA1 neuronal firing in Ca2+-free solution. * Selected: true ---- * ID: 12562909 * Author: Lian J, Bikson M, Sciortino C, Stacey WC, Durand DM. * Volume: 547 * Issue: Pt 2 * Year: 2003 * Date: 2003 Mar 1 * Journal: J Physiol * Pages: 427-434 * Title: Local suppression of epileptiform activity by electrical stimulation in rat hippocampus in vitro. * Status: 2003/01/24 [aheadofprint] * Selected: true ---- * ID: 12424297 * Author: Stacey WC, Durand DM. * Volume: 88 * Issue: 5 * Year: 2002 * Date: 2002 Nov * Journal: J Neurophysiol * Pages: 2598-2611 * Title: Noise and coupling affect signal detection and bursting in a simulated physiological neural network. * Selected: true ---- * ID: 11784730 * Author: Bikson M, Baraban SC, Durand DM. * Volume: 87 * Issue: 1 * Year: 2002 * Date: 2002 Jan * Journal: J Neurophysiol * Pages: 62-71 * Title: Conditions sufficient for nonsynaptic epileptogenesis in the CA1 region of hippocampal slices. * Selected: true ---- * ID: 11711572 * Author: Lian J, Bikson M, Shuai J, Durand DM. * Volume: 537 * Issue: Pt 1 * Year: 2001 * Date: 2001 Nov 15 * Journal: J Physiol * Pages: 191-199 * Title: Propagation of non-synaptic epileptiform activity across a lesion in rat hippocampal slices. * Selected: true ---- * ID: 11585040 * Author: Hsu KH, Durand DM. * Volume: 48 * Issue: 10 * Year: 2001 * Date: 2001 Oct * Journal: IEEE Trans Biomed Eng * Pages: 1162-1168 * Title: A 3-D differential coil design for localized magnetic stimulation. * Selected: true ---- * ID: 11535661 * Author: Stacey WC, Durand DM. * Volume: 86 * Issue: 3 * Year: 2001 * Date: 2001 Sep * Journal: J Neurophysiol * Pages: 1104-1112 * Title: Synaptic noise improves detection of subthreshold signals in hippocampal CA1 neurons. * Selected: true ---- * ID: 11524575 * Author: Hahn PJ, Durand DM. * Volume: 11 * Issue: 1 * Year: 2001 * Date: 2001 Jul-Aug * Journal: J Comput Neurosci * Pages: 5-18 * Title: Bistability dynamics in simulations of neural activity in high-extracellular-potassium conditions. * Selected: true ---- * ID: 11497690 * Author: Shuai JW, Lian J, Hahn PJ, Durand DM. * Volume: 64 * Issue: 2 Pt 2 * Year: 2001 * Date: 2001 Aug * Journal: Phys Rev E Stat Nonlin Soft Matter Phys * Pages: 026220 * Title: Positive Lyapunov exponents calculated from time series of strange nonchaotic attractors. * Status: 2001/07/23 [aheadofprint] * Selected: true ---- * ID: 11322531 * Author: Carbunaru R, Durand DM. * Volume: 48 * Issue: 4 * Year: 2001 * Date: 2001 Apr * Journal: IEEE Trans Biomed Eng * Pages: 434-441 * Title: Toroidal coil models for transcutaneous magnetic stimulation of nerves. * Selected: true * Student: true ---- * ID: 11296872 * Author: Choi AQ, Cavanaugh JK, Durand DM. * Volume: 48 * Issue: 2 * Year: 2001 * Date: 2001 Feb * Journal: IEEE Trans Biomed Eng * Pages: 165-172 * Title: Selectivity of multiple-contact nerve cuff electrodes: a simulation analysis. * Selected: true ---- * ID: 11179402 * Author: Bikson M, Lian J, Hahn PJ, Stacey WC, Sciortino C, Durand DM. * Volume: 531 * Issue: Pt 1 * Year: 2001 * Date: 2001 Feb 15 * Journal: J Physiol * Pages: 181-191 * Title: Suppression of epileptiform activity by high frequency sinusoidal fields in rat hippocampal slices. * Selected: true * Student: true ---- * ID: 11164790 * Author: Lian J, Shuai J, Hahn P, Durand DM. * Volume: 890 * Issue: 2 * Year: 2001 * Date: 2001 Feb 2 * Journal: Brain Res * Pages: 246-254 * Title: Nonlinear dynamic properties of low calcium-induced epileptiform activity. * Selected: true ---- * ID: 11001512 * Author: Perez-Orive J, Durand DM. * Volume: 8 * Issue: 3 * Year: 2000 * Date: 2000 Sep * Journal: IEEE Trans Rehabil Eng * Pages: 320-329 * Title: Modeling study of peripheral nerve recording selectivity. * Selected: true * Student: true ---- * ID: 10916263 * Author: Sahin M, Durand DM, Haxhiu MA. * Volume: 47 * Issue: 7 * Year: 2000 * Date: 2000 Jul * Journal: IEEE Trans Biomed Eng * Pages: 919-925 * Title: Closed-loop stimulation of hypoglossal nerve in a dog model of upper airway obstruction. * Selected: true * Student: true ---- * ID: 10899202 * Author: Ghai RS, Bikson M, Durand DM. * Volume: 84 * Issue: 1 * Year: 2000 * Date: 2000 Jul * Journal: J Neurophysiol * Pages: 274-280 * Title: Effects of applied electric fields on low-calcium epileptiform activity in the CA1 region of rat hippocampal slices. * Selected: true * Student: true ---- * ID: 10779106 * Author: Cuoco FA Jr, Durand DM. * Volume: 8 * Issue: 1 * Year: 2000 * Date: 2000 Mar * Journal: IEEE Trans Rehabil Eng * Pages: 35-41 * Title: Measurement of external pressures generated by nerve cuff electrodes. * Selected: true ---- * ID: 10763292 * Author: Hsu KH, Durand DM. * Volume: 47 * Issue: 4 * Year: 2000 * Date: 2000 Apr * Journal: IEEE Trans Biomed Eng * Pages: 463-471 * Title: Prediction of neural excitation during magnetic stimulation using passive cable models. * Selected: true * Student: true ---- * ID: 10712466 * Author: Stacey WC, Durand DM. * Volume: 83 * Issue: 3 * Year: 2000 * Date: 2000 Mar * Journal: J Neurophysiol * Pages: 1394-1402 * Title: Stochastic resonance improves signal detection in hippocampal CA1 neurons. * Selected: true * Student: true ---- * ID: 10601168 * Author: Sahin M, Durand DM, Haxhiu MA. * Volume: 87 * Issue: 6 * Year: 1999 * Date: 1999 Dec * Journal: J Appl Physiol * Pages: 2197-2206 * Title: Chronic recordings of hypoglossal nerve activity in a dog model of upper airway obstruction. * Selected: false * Student: true ---- * ID: 10561404 * Author: Bikson M, Ghai RS, Baraban SC, Durand DM. * Volume: 82 * Issue: 5 * Year: 1999 * Date: 1999 Nov * Journal: J Neurophysiol * Pages: 2262-2270 * Title: Modulation of burst frequency, duration, and amplitude in the zero-Ca(2+) model of epileptiform activity. * Selected: false * Student: true ---- * ID: 10391589 * Author: Qi H, Tyler DJ, Durand DM. * Volume: 7 * Issue: 2 * Year: 1999 * Date: 1999 Jun * Journal: IEEE Trans Rehabil Eng * Pages: 183-192 * Title: Neurofuzzy adaptive controlling of selective stimulation for FES: a case study. * Selected: false * Postdoc: true ---- * ID: 10344411 * Author: Patil MM, Durand DM, LaManna JC, Whittingham TS, Haxhiu MA. * Volume: 115 * Issue: 1 * Year: 1999 * Date: 1999 Jan 1 * Journal: Respir Physiol * Pages: 11-22 * Title: Effects of oxygen deprivation on parapyramidal neurons of the ventrolateral medulla in the rat. * Selected: false * Student: true ---- * ID: 9826597 * Author: Bertrand CA, Durand DM, Saidel GM, Laboisse C, Hopfer U. * Volume: 75 * Issue: 6 * Year: 1998 * Date: 1998 Dec * Journal: Biophys J * Pages: 2743-2756 * Title: System for dynamic measurements of membrane capacitance in intact epithelial monolayers. * Selected: false ---- * ID: 9739139 * Author: Warren RJ, Durand DM. * Volume: 806 * Issue: 2 * Year: 1998 * Date: 1998 Sep 28 * Journal: Brain Res * Pages: 186-195 * Title: Effects of applied currents on spontaneous epileptiform activity induced by low calcium in the rat hippocampus. * Selected: false * Student: true ---- * ID: 9691579 * Author: Sahin M, Durand DM. * Volume: 45 * Issue: 8 * Year: 1998 * Date: 1998 Aug * Journal: IEEE Trans Biomed Eng * Pages: 1044-1050 * Title: Improved nerve cuff electrode recordings with subthreshold anodic currents. * Selected: false * Student: true ---- * ID: 9582210 * Author: Klemic KG, Durand DM, Jones SW. * Volume: 79 * Issue: 5 * Year: 1998 * Date: 1998 May * Journal: J Neurophysiol * Pages: 2345-2357 * Title: Activation kinetics of the delayed rectifier potassium current of bullfrog sympathetic neurons. * Selected: false ---- * ID: 9358449 * Author: Carbunaru R, Durand DM. * Volume: 38 * Issue: 5 * Year: 1997 * Date: 1997 Nov * Journal: Magn Reson Med * Pages: 750-758 * Title: Axonal stimulation under MRI magnetic field z gradients: a modeling study. * Selected: false * Student: true ---- * ID: 9356398 * Author: Lyubkin M, Durand DM, Haxhiu MA. * Volume: 78 * Issue: 5 * Year: 1997 * Date: 1997 Nov * Journal: J Neurophysiol * Pages: 2475-2482 * Title: Interaction between tetanus long-term potentiation and hypoxia-induced potentiation in the rat hippocampus. * Selected: false * Student: true ---- * ID: 9216978 * Author: Sahin M, Haxhiu MA, Durand DM, Dreshaj IA. * Volume: 83 * Issue: 1 * Year: 1997 * Date: 1997 Jul * Journal: J Appl Physiol * Pages: 317-322 * Title: Spiral nerve cuff electrode for recordings of respiratory output. * Selected: false * Student: true ---- * ID: 9086385 * Author: Tyler DJ, Durand DM. * Volume: 5 * Issue: 1 * Year: 1997 * Date: 1997 Mar * Journal: IEEE Trans Rehabil Eng * Pages: 51-61 * Title: A slowly penetrating interfascicular nerve electrode for selective activation of peripheral nerves. * Selected: false * Student: true ---- * ID: 9214797 * Author: Durand DM, Lin JC. * Volume: 44 * Issue: 2 * Year: 1997 * Date: 1997 Feb * Journal: IEEE Trans Biomed Eng * Pages: 177-187 * Title: Theoretical study of magnetic field of current monopoles in special volume conductor using symmetry analysis. * Selected: false ---- * ID: 9124726 * Author: Nagarajan SS, Durand DM, Hsuing-Hsu K. * Volume: 25 * Issue: 1 * Year: 1997 * Date: 1997 Jan-Feb * Journal: Ann Biomed Eng * Pages: 112-125 * Title: Mapping location of excitation during magnetic stimulation: effects of coil position. * Selected: false * Student: true ---- * ID: 7558067 * Author: Nagarajan SS, Durand DM. * Volume: 42 * Issue: 9 * Year: 1995 * Date: 1995 Sep * Journal: IEEE Trans Biomed Eng * Pages: 926-933 * Title: Analysis of magnetic stimulation of a concentric axon in a nerve bundle. * Selected: false * Student: true ---- * ID: 7605049 * Author: Nagarajan SS, Durand DM, Roth BJ, Wijesinghe RS. * Volume: 23 * Issue: 2 * Year: 1995 * Date: 1995 Mar-Apr * Journal: Ann Biomed Eng * Pages: 116-126 * Title: Magnetic stimulation of axons in a nerve bundle: effects of current redistribution in the bundle. * Selected: false * Student: true )# #template?query=Selected&key=Durand(publications.php|...)# ===== POSTDOCTORAL FELLOW FIRST AUTHORED PAPERS ===== #template?query=Postdoc&key=Durand(publications.php|...)# ===== GRADUATE STUDENT FIRST AUTHOR PUBLICATIONS ===== #template?query=Student&key=Durand(publications.php|...)# #template?key=Durand(dokudata.php|...)# ===== JOB PLACEMENT OF STUDENTS AND POSTDOCS ===== #template(current_positions.php|... * Title_1: Postdoc or R.A. / Period * Title_2: Current Position ---- * Name: Mesut Sahin \\ Jul-98 to * Position: Research Associate ---- * Name: Jian-Wei Shuai \\ Jun-98 to * Position: Research Associate ---- * Name: Johannes Strujk \\ Jul-98 to * Position: Visiting Professor (University of Aalborg), \\ Associate Professor, Aalborg University ---- * Name: Lin, Jian-Cheng \\ Oct94-98 * Position: Senior Research Associate ---- * Name: Qi, Haiming \\ Oct96-98 * Position: Senior Res. Associate, \\ Research associate, University of British Colombia) ---- * Name: Tawfik, Bassel \\ Jul97-Sep97 * Position: Visiting Professor, \\ Associate professor, (University of Cairo) )# (space) #template(current_positions.php|... * Title_1: Ph.D. Student / Grad * Title_2: Thesis / Current Position ---- * Name: Srikantan Nagaranjan \\ Dec-94 * Position: //"Theoretical and Experimental Analysis of Magnetic stimulation of Neuronal System."// \\ Assistant Professor, University of Utah, Biomedical Engineering. ---- * Name: Madhavi Patil \\ May-95 * Position:// "Effect of hypoxia on the nervous system."// \\ Post-doctoral fellow, Harvard University. ---- * Name: Mesut Sahin \\ May-98 * Position: "Chronic recording and stimulation of the hypoglossal nerve in dogs for obstructive sleep apnea." \\ Research Associate, CWRU, Biomedical Engineering. ---- * Name: Anila Jahangiri \\ May-98 * Position: //"Phase Resetting analysis of high potassium epileptiforma activity." // \\ Engineer: VI Engineering, Inc. ---- * Name: Dustin Tyler \\ May-99 * Position: //"Functional Electrical Stimulation of Peripheral nerve: electrodes that alter nerve geometry."// \\ Scientist, Neurocontrol, Inc. ---- * Name: Rafael Carbunaru \\ May-99 * Position: //"Coil design for efficient and localized magnetic stimulation of the nervous system."// \\ Research Scientist, Advanced Bionics. ---- * Name: Kai-Hsiung Hsu \\ Aug-00 * Position: //"Analysis of excitation characteristics of Magnetic stimulation."// ---- * Name: William Stacey \\ Aug-00 * Position: //"Stochastic resonance in the hippocampus."// \\ Medical Student, CWRU )# (space) #template(current_positions.php|... * Title_1: Ms.C. Student / Grad * Title_2: Thesis / Current Position ---- * Name: K.S. Hsu \\ May-96 * Position: //"Determination of excitation of nerve fibers during magnetic stimulation."// ---- * Name: J. Cavanaugh \\ May-96 * Position: //"Finite element analysis of electrical nerve stimulation."// \\ Engineer, General Electric. ---- * Name: Frank Cuoco \\ May-96 * Position: //"Measurement of external pressure generated by nerve electrodes."// \\ Medical Student Georgetown University ---- * Name: Rafael Carbunaru \\ May-96 * Position: //"Axonal stimulation under MRI Z-gradient magnetic fields: a modelling study."// \\ Scientist, Advanced Bionics. ---- * Name: Jim Warren \\ Dec-96 * Position: //"Control of low calcium activity with applied currents."// \\ Medical Student, University of Cincinnati. ---- * Name: Albert Guzman \\ Dec-97 * Position: //"Detection of tactile slip using the power spectrum of spiral cuff recordings from sensory nerve."// \\ Engineer, Cyberonics. ---- * Name: Rahul S. Ghai \\ May-98 * Position: //"Electric field suppression of spontaneous low calcium epileptifirm activity in the CA1 region of rat hippocampal slices."// \\ Consultant, Deloitte and Touche. ---- * Name: J. Perez Orive \\ Dec-98 * Position: //"Modelling study of peripheral nerve recording selectivity."// \\ Graduate student, California Institute of Technology. ---- * Name: Adam Choi \\ Dec-98 * Position: //Nerve electrode design for improved selectivity."// ---- * Name: Andrea Oates \\ May-00 * Position: //"Measurement of the impedance of the Dura matter."// )# (space) ~~NOTOC~~