====== Evan S. Deneris, Ph.D. ====== #template(faculty_profile.php|... * FName: Evan S. * LName: Deneris * Degree: Ph.D. * Picture: deneris-1.jpg * Position: Professor * Department: Department of Neurosciences * Organization: Case Western Reserve University * Address_1: School of Medicine * Address_2: 10900 Euclid Ave * Address_3: Cleveland OH, 44106-4975 * Phone: (216) 368-8725 * Fax: (216) 368-4650 * Email: esd@case.edu * PubMed_Search: Deneris E + Case Western )# ===== RESEARCH INTERESTS ===== Research in the Deneris lab is focused on the transcriptional regulatory mechanisms that govern the development of vertebrate neurotransmitter systems. Two projects are currently being pursued in the lab. One is focused on the brain [[serotonin system|serotonin system]] and the second is focused on the [[nicotinic cholinergic system|nicotinic cholinergic system]] of the brain and peripheral nervous system. Our investigation of the serotonin system is aimed at identifying the transcriptional mechanisms that control the development of serotonin neurons and how these mechanisms impact serotonergic modulation of behavior. Our investigation of the cholinergic system is focused on how nicotinic cholinergic receptor subunit genes are coordinately controlled in neurons in order to express appropriate receptor subtypes at synapses. We are using mouse molecular genetics to investigate both of these problems in conjunction with biochemical, histological, and behavioral approaches. ===== SELECTED PUBLICATIONS ===== #template?key=Deneris(dokudata.php|... * ID: 16251278 * Author: Krueger, K.C. and Deneris, E.S. * Volume: 28 * Year: 2008 * Journal: J. Neurosci * Pages: 12748-12758 * Title: Serotonergic transcription of human FEV reveals direct GATA factor interactions and fate of Pet-1 deficient serotonin neuron precursors. * Selected: true ---- * ID: 16251278 * Author: Lerch-Haner, J.K., Frierson, D., Crawford, L., Beck, S. and Deneris, E.S. * Volume: 11 * Year: 2008 * Journal: Nat. Neurosci. * Pages: 1001-1003 * Title: Serotonergic transcriptional programming determines maternal behavior and offspring survival. * Selected: true ---- * ID: 16251278 * Author: Jensen, P., Farago, A.F., Awatramani, R.B., Scott, M.M., Deneris, E.S. and Dymecki, S.M. * Volume: 11 * Year: 2008 * Journal: Nat. Neurosci. * Pages: 417-419 * Title: Redefining the central serotonergic system based on genetic lineage. * Selected: true ---- * ID: 16251278 * Author: Hodges, M.R., Tattersall, G.J., Harris, M.B., McEvoy, S.D., Richerson, D.N., Deneris, E.S., Johnson, R. L., Chen, Z. F., Richerson, G.B. * Volume: 28 * Year: 2008 * Journal: J. Neurosci. * Pages: 2495-2505 * Title: Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons, has been received. * Selected: true ---- * ID: 16251278 * Author: Erickson, J.T., Shafer, G., Rossetti, M.D., Wilson, C. G., and Deneris, E.S. * Volume: 159 * Year: 2007 * Journal: Respir. Physiol. Neurobiol. * Pages: 85-101 * Title: Arrest of 5HT neuron differentiation delays respiratory maturation and impairs neonatal homeostatic responses to environmental challenges * Selected: true ---- * ID: 16251278 * Author: *Zhao, Z. Q., *Scott, M.M., Chiechio, S., Wang, J.S., Renner, K.J., Gereau, R.W. IV Johnson, R.L., Deneris, E.S., and Chen, Z.F. * Volume: 26 * Year: 2006 * Journal: J. Neurosci * Pages: 12781-12788 * Title: Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotive activity. * Selected: true ---- * ID: 16251278 * Author: Xu, X, Scott, M.M. and Deneris, E. * Volume: 26 * Year: 2006 * Journal: Mol. Cell. Biol. * Pages: 5636-5649 * Title: Shared long-range regulatory elements coordinate expression of a gene cluster encoding nicotinic receptor heteromeric subtypes * Selected: true ---- * ID: 16251278 * Author: Scott, M.S., Wylie, C.W., Lerch, J.K., Murphy, R., Lobur, K., Herlitze, S., Jiang, W., Conlon, R.A., Strowbridge, B., and Deneris, E.S. * Volume: 102 * Issue: 45 * Year: 2005 * Date: 2005 Nov 8 * Journal: PNAS * Pages: 16472-16477 * Title: A genetic approach to access serotonin neurons for in vivo and in vitro studies. * Status: 2005/10/26 [aheadofprint] * Selected: true ---- * ID: 15758173 * Author: Scott MM, Krueger KC, Deneris ES. * Volume: 25 * Issue: 10 * Year: 2005 * Date: 2005 Mar 9 * Journal: J Neurosci * Pages: 2628-2636 * Title: A differentially autoregulated Pet-1 enhancer region is a critical target of the transcriptional cascade that governs serotonin neuron development. * Selected: true ---- * ID: 15749252 * Author: Scott MM, Deneris ES. * Volume: 23 * Issue: 2-3 * Year: 2005 * Date: 2005 Apr-May * Journal: Int J Dev Neurosci * Pages: 277-285 * Title: Making and breaking serotonin neurons and autism. * Selected: true ---- * ID: 12546819 * Author: Hendricks TJ, Fyodorov DV, Wegman LJ, Lelutiu NB, Pehek EA, Yamamoto B, Silver J, Weeber EJ, Sweatt JD, Deneris ES. * Volume: 37 * Issue: 2 * Year: 2003 * Date: 2003 Jan 23 * Journal: Neuron * Pages: 233-247 * Title: Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. * Selected: true ---- * ID: 11734552 * Author: Francis N, Deneris ES. * Volume: 277 * Issue: 8 * Year: 2002 * Date: 2002 Feb 22 * Journal: J Biol Chem * Pages: 6511-6519 * Title: Retinal neuron activity of ETS domain-binding sites in a nicotinic acetylcholine receptor gene cluster enhancer. * Status: 2001/12/04 [aheadofprint] * Selected: true ---- * ID: 11169504 * Author: Zhou Y, Deneris E, Zigmond RE. * Volume: 46 * Issue: 3 * Year: 2001 * Date: 2001 Feb 15 * Journal: J Neurobiol * Pages: 178-192 * Title: Nicotinic acetylcholine receptor subunit proteins alpha7 and beta4 decrease in the superior cervical ganglion after axotomy. * Selected: true ---- * ID: 10878018 * Author: McDonough J, Francis N, Miller T, Deneris ES. * Volume: 275 * Issue: 37 * Year: 2000 * Date: 2000 Sep 15 * Journal: J Biol Chem * Pages: 28962-28970 * Title: Regulation of transcription in the neuronal nicotinic receptor subunit gene cluster by a neuron-selective enhancer and ETS domain factors. * Selected: true ---- * ID: 10770999 * Author: Deneris ES, Francis N, McDonough J, Fyodorov D, Miller T, Yang X. * Volume: 393 * Issue: 1-3 * Year: 2000 * Date: 2000 Mar 30 * Journal: Eur J Pharmacol * Pages: 69-74 * Title: Transcriptional control of the neuronal nicotinic acetylcholine receptor gene cluster by the beta43' enhancer, Sp1, SCIP and ETS transcription factors. * Selected: true ---- * ID: 10575032 * Author: Hendricks T, Francis N, Fyodorov D, Deneris ES. * Volume: 19 * Issue: 23 * Year: 1999 * Date: 1999 Dec 1 * Journal: J Neurosci * Pages: 10348-10356 * Title: The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. * Selected: true ---- * ID: 9468387 * Author: Zhou Y, Deneris E, Zigmond RE. * Volume: 34 * Issue: 2 * Year: 1998 * Date: 1998 Feb 5 * Journal: J Neurobiol * Pages: 164-178 * Title: Differential regulation of levels of nicotinic receptor subunit transcripts in adult sympathetic neurons after axotomy. * Selected: true ---- * ID: 9468386 * Author: Fyodorov D, Nelson T, Deneris E. * Volume: 34 * Issue: 2 * Year: 1998 * Date: 1998 Feb 5 * Journal: J Neurobiol * Pages: 151-163 * Title: Pet-1, a novel ETS domain factor that can activate neuronal nAchR gene transcription. * Selected: true ---- * ID: 9065489 * Author: McDonough J, Deneris E. * Volume: 17 * Issue: 7 * Year: 1997 * Date: 1997 Apr 1 * Journal: J Neurosci * Pages: 2273-2283 * Title: beta43': An enhancer displaying neural-restricted activity is located in the 3'-untranslated exon of the rat nicotinic acetylcholine receptor beta4 gene. * Selected: true ---- * ID: 9058323 * Author: Yang X, Yang F, Fyodorov D, Wang F, McDonough J, Herrup K, Deneris E. * Volume: 32 * Issue: 3 * Year: 1997 * Date: 1997 Mar * Journal: J Neurobiol * Pages: 311-324 * Title: Elements between the protein-coding regions of the adjacent beta 4 and alpha 3 acetylcholine receptor genes direct neuron-specific expression in the central nervous system. * Selected: true ---- * ID: 8756659 * Author: Fyodorov D, Deneris E. * Volume: 16 * Issue: 9 * Year: 1996 * Date: 1996 Sep * Journal: Mol Cell Biol * Pages: 5004-5014 * Title: The POU domain of SCIP/Tst-1/Oct-6 is sufficient for activation of an acetylcholine receptor promoter. * Selected: true ---- * ID: 7721749 * Author: Yang X, Fyodorov D, Deneris ES. * Volume: 270 * Issue: 15 * Year: 1995 * Date: 1995 Apr 14 * Journal: J Biol Chem * Pages: 8514-8520 * Title: Transcriptional analysis of acetylcholine receptor alpha 3 gene promoter motifs that bind Sp1 and AP2. * Selected: true ---- * ID: 8144606 * Author: Yang X, McDonough J, Fyodorov D, Morris M, Wang F, Deneris ES. * Volume: 269 * Issue: 14 * Year: 1994 * Date: 1994 Apr 8 * Journal: J Biol Chem * Pages: 10252-10264 * Title: Characterization of an acetylcholine receptor alpha 3 gene promoter and its activation by the POU domain factor SCIP/Tst-1. * Selected: true ---- * ID: 2006540 * Author: Deneris ES, Connolly J, Rogers SW, Duvoisin R. * Volume: 12 * Issue: 1 * Year: 1991 * Date: 1991 Jan * Journal: Trends Pharmacol Sci * Pages: 34-40 * Title: Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors. * Selected: true )# #template?query=Selected&key=Deneris(publications.php|...)# #template?key=Deneris(dokudata.php|...)# ~~NOTOC~~