CWRU Rodent Behavior Core

Mission Statement

The goal of the Rodent Behavior Core in the School of Medicine is to conduct state of the art rodent behavioral testing for investigators at Case and other nearby institutions. The core facility is equipped to perform a comprehensive battery of behavioral tests to thoroughly phenotype overall motor and sensory function of rats and mice as well as phenotype specific behaviors that are of interest to the investigators (learning and memory, motor function and gaiting, place/fear conditioning, pain/analgesia, and anxiety-related behaviors). The Core can assist in all aspects of rodent behavioral testing including design and execution of behavioral tasks as well as data analysis and interpretation. The Core laboratory is located in HSAF and a small satellite facility is located in the Wolstein Building for preliminary behavioral testing.

Contact Information

Gemma Casadesus PhD – Core Director
Case Western Reserve University
School of Medicine
Department of Neurosciences
Cleveland OH 44106
Tel:216-368-8503
Fax:216-368-4650
Email: gxc40@case.edu / gemma.casadesus@case.edu

General guidelines for service

The first event that needs to take place is the submission of the Behavior Order Form (found on this website), via email or fax, to the Core. Once the form is submitted the Core will contact you with a formal quote and move day of the animals will be determined. An initial consulting session can also be set up with the director if the PI has questions about specific testing or if the PI is interested in measuring behavior but is not clear on what to measure. Consulting includes guidance on: Appropriate age, background, number of animals to test, as well as most appropriate tests based on the PIs specific goals. Once the animals are received they will wait in the housing facility for 7-10 days to acclimatize to the new rooms and handling by husbandry and Core personnel that will be carrying out the testing. During acclimatization, animals will be handled daily until testing begins. After testing is completed, the Core will contact the PI with the summarized & raw data and a time will be arranged for pick up of the animals. In the event that the PI desires the Core to do the statistical analyses and data interpretation, a second visit with the Core director will be scheduled to go over the results. If the PI does not wish to keep the animals, the Core can dispose of them for a small fee.

Training & Test Development Possibilities

We now offer the possibility of training students on a selection of standard tests for a small fee. Upon completion of training, students/investigators can be added to the IACUC protocol and can carry out unsupervised testing on the tasks that they have been trained on upon room availability or after-hours for a small hourly fee. Additionally, if a student/PI wishes to develop a test that is not in our list we can work with them to develop it (upon IACUC approval). Students/investigators, in this case, can work alongside the Core staff (no training fee). Once testing is optimized the student can be added to the Core IACUC protocol and carry out the testing unsupervised for a small hourly fee. (See pricing for details on fees).


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