• Wednesday 3:30-5:00pm
• Friday 2:00-3:30pm
• Room: SOM E609

• Evan Deneris (x8725, esd@case.edu)

• Stefan Herlitze (x1804, sxh106@case.edu)
• Evan Deneris (x8725, esd@case.edu)
• Gary Landreth (x6101, gel2@case.edu)
• David Friel (x4930, ddf2@case.edu)
• Sofia Sundararajan

• Channel structure and function
  • Voltage gated ion channels I: K+ and Na+ channels; gating and inactivation
  • Voltage gated ion channels II: Ca2+ channels; modulation
  • Gap junctions

• Ligand gated ion channel structure and function
  • Ligand gated ion channels I: nAChR, GluR and P2X
  • Ligand gated ion channels II: GABAR and GlyR

• Intracellular neuronal trafficking
  • Ion channel trafficking

• Calcium-dependent transcription in neurons
• Molecular mechanisms underlying behavior
  • Circadian Rhythms I: Genetic of intrinsic timekeeping
  • Circadian Rhythms II: Resetting the clock
  • Learning and memory I: Role of calcium-dependent CREB transcription in flies
  • Learning and memory II: Role of calcium-dependent CREB transcription in mice

• Intercellular neuronal signaling
• Diseases of the nervous system
  • Alzheimer’s disease
  • Trinucleotide repeat disorders

• Membrane Excitability
  • Membrane potential and ion concentration dynamics: essential concepts
  • The basis of threshold behavior and modulation of excitability
  • Spontaneus electrical activity: Contributions from persistent Na⁺ currents
• Synaptic Transmission
  • Synaptic Vesicle Cycling
  • Evoked [Ca2+] elevation that trigger neurotransmitter release
  • Ca²⁺ release from stores and its role in stimulating neurotransmitter release

As the semester progresses, the entries under “Papers” and “Notes” will become active links to assigned readings (as pdf’s), problem sets, and powerpoints from lectures and possibly also from student presentations.